Development of Resolution Processes
Much of Dr. Stahly's career was spent in the area of chiral chemistry, predominantly in generation of enantiomerically pure materials. While asymmetric synthesis is being used commercially, diastereomeric salt crystallization remains the industrial workhorse for production of pure enantiomers. An understanding of solid-state chemistry is crucial for planning, developing, and troubleshooting crystallization-based resolution processes.
Generation of the binary phase diagram of a racemic mixture, either experimentally or by calculation, is a critical first step in planning a resolution. Chemfocus can guide you through an understanding of the solid-state chemistry of racemates and enantiomers, collection of necessary background information, selection of the appropriate resolution method, and generation of a robust process.