Improvement of Drug Properties

Different solid forms of an active pharmaceutical ingredient (API) can have very different properties. Those differences can impact bioavailability, solubility, dissolution rate, first pass metabolism, side effect incidence, stability, API and drug product manufacturability, and other important parameters. The vast majority of APIs can exist in multiple solid forms, including polymorphs, hydrates, solvates, salts, cocrystals, dispersions, and non-crystalline forms.

Chemfocus has extensive experience in devising programs to improve drug properties, and can assist in conducting such a program in your laboratories or recommend a CRO to carry it out.

If your API has poor aqueous solubility, there are types of solid forms that can be found and patented that will lead to improved solubility.
If your drug has poor stability or handling properties, Chemfocus can recommend approaches to improve those properties.
If you are a generic company or innovator looking for an improved version of a generic drug to patent and market for increased profitability, Chemfocus can suggest strategies to produce the improved product through use of novel, patentable solid forms.
Searching for and patenting new solid forms several years before patent expiration of a drug is a very valuable lifecycle management technique. Chemfocus can recommend the types of studies that will result in novel forms and lead to development of improved, patentable product extensions.